The first unveiling will honor civil rights activist, surgeon and businessman Dr. T.R.M. Howard and will take place at 2 p.m. at 203 Edwards Avenue in Mound Bayou.
At 4 p.m., the second stop will honor Cleveland’s own leading activist, Amzie Moore.
Moore's marker will be unveiled at his former home at 614 Chrisman Avenue in Cleveland.
These events are free and open to the public.
Sarah McCullough, cultural heritage development program manager with the Mississippi Development Authority Division of Tourism, said today's commemorations pay tribute to two impactful Deltans.
"It is important we recognize this history and the significant role Mississippians played in American history," said McCullough. "Both Moore and Howard were critical to this history."
Howard and Moore worked jointly in 1951 to help form the Regional Council of Negro Leadership.
The RCNL encouraged entrepreneurship, self-help and civil rights for African-Americans in the Mississippi Delta.
Both pioneers also played a prominent role in the investigation of the kidnapping and murder of Emmett Till in Money, Miss.
"Moore often allowed activists to come to his home and he was very openly involved," said McCullough. "He also saw the need for student involvement, and was therefore instrumental in organizing the Freedom Summer of 1964."
"Dr. Howard was both a physician and community leader who had very close ties to Medgar Evers," added McCullough. "He is remembered for attempting to reconcile with the white community."
The Mississippi Freedom Trail project began when two participants on a heritage tour conducted by the Delta State University Delta Center for Culture and Learning volunteered to fund the first two stops on the trail.
Funding is now available for thirty stops.
Most recently, the state unveiled a marker honoring James Meredith at Ole Miss commemorating the 50th anniversary of his enrollment, which prompted the end of the university's official policy of racial segregation.
For more information on the Mississippi Freedom Trail, go online to www.visitmississippi.org.